Parallels between the mechanisms by which CMG mutations block C. elegans cell fate divergence and cause human NK cell deficiency

Ninnin Reanchareonsuk

Parallels between the mechanisms by which CMG mutations block C. elegans cell fate divergence and cause human NK cell deficiency

Authors

Ninnin Reanchareonsuk

Abstract

The CMG (Cdc45–MCM–GINS) helicase is classically responsible for unwinding DNA at the replication fork during cell division.
Beyond this, CMG also plays a role in epigenetic inheritance: how histones and their modifications are passed on during replication.
Mutations in CMG are linked to:
• Block in cell death fate in C. elegans
• Natural Killer cell deficiency (NKD) in humans
Emerging evidence on C. elegans and mice embryonic stem cells (ESCs) suggest an epigenetic mechanism.
Both phenotypes arise from disruptions in lineage specification, indicating a potentially shared mechanism

References

Guilz, N. C., Ahn, Y .- O., Seo, S., & Mace, E. M. (2023). Unwinding the Role of the CMG Helicase in Inborn Errors of Immunity, Journal of Clinical Immunology, 43(5), 847-861. https://doi.org/10.1007/s10875-023-01437-3

Memar, N., Sherrard, R., Sethi, A., Fernandez, C. L., Schmidt, H., Lambie, E. J., Poole, R. J., Schnabel, R., & Conradt, B, 2024). The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo. Nature Communications 15(1), 9399. https://doi.org/10.1038/s41467-024-53715-2

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Published

14-11-2026

How to Cite

Reanchareonsuk, N. (2026) “Parallels between the mechanisms by which CMG mutations block C. elegans cell fate divergence and cause human NK cell deficiency”, Society for Natural Sciences Student Journal, 4. Available at: https://www.journal.socnatsci.org/index.php/journal/article/view/55 (Accessed: 14 November 2026).